- #Monte carlo simulation tools crystal ball fusion software#
- #Monte carlo simulation tools crystal ball fusion simulator#
The driving force of dMRI is to monitor natural microscopic displacements of water molecules that occur in brain tissues as part of the physical diffusion process. More recently, it has been shown that dMRI can also be used to deliver direct features of tissue microstructures, ,, , as well as to detect changes in brain regions associated with neuronal activation. It is also rapidly becoming a standard for white matter (WM) disorders, as diffusion tensor (DT) imaging can reveal abnormalities in WM fiber structure and provide outstanding maps of brain connectivity. Its major clinical domain of application has been neurological disorders, especially for the management of patients with acute ischemic stroke. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist.ĭiffusion magnetic resonance imaging (or dMRI) came into existence in the mid-1980s, ,, and during the past 25 years, dMRI has been extraordinarily successful, particularly in MRI of the central nervous system. CHY is grateful to the “Programme Joseph Fourier (2008–2010)” scholarship co-financed by the French Institute in Taipei, the CEA NeuroSpin Centre, and National Yang-Ming University. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.įunding: This research is partly supported by the National Science Council of Taiwan, the Partenariat Huber Currier Orchid project, the DFMRI and SimuDMRI projects approved by the French National Research Agency, and the European CONNECT project. Received: Accepted: AugPublished: October 10, 2013Ĭopyright: © 2013 Yeh et al. PLoS ONE 8(10):Įditor: Wang Zhan, University of Maryland, College Park, United States of America
#Monte carlo simulation tools crystal ball fusion software#
We expect that this novel software tool would be substantially advantageous to clarify the interrelationship between dMRI and the microscopic characteristics of brain tissues, and to advance the biophysical modeling and the dMRI methodologies.Ĭitation: Yeh C-H, Schmitt B, Le Bihan D, Li-Schlittgen J-R, Lin C-P, Poupon C (2013) Diffusion Microscopist Simulator: A General Monte Carlo Simulation System for Diffusion Magnetic Resonance Imaging. The validity, efficiency, and potential applications of DMS are evaluated through four benchmark experiments, including the simulated dMRI of white matter fibers, the multiple scattering diffusion imaging, the biophysical modeling of polar cell membranes, and the high angular resolution diffusion imaging and fiber tractography of complex fiber configurations.
The aims of DMS are to give insights into the link between the fundamental diffusion process in biological tissues and the features observed in dMRI, as well as to provide appropriate ground-truth information for the development, optimization, and validation of dMRI acquisition schemes for different applications. The former has the capacity to perform large-scale simulations of Brownian dynamics in the virtual environments of neural tissues at various levels of complexity, and the latter is flexible enough to synthesize dMRI datasets from a variety of simulated MRI pulse sequences.
#Monte carlo simulation tools crystal ball fusion simulator#
DMS comprises a random walk Monte Carlo simulator and an MR image synthesizer.
This article describes the development and application of an integrated, generalized, and efficient Monte Carlo simulation system for diffusion magnetic resonance imaging (dMRI), named Diffusion Microscopist Simulator (DMS).